Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography.
Oligodeoxynucleotides incorporating internucleotide phosphoroselenolate linkages have been ready beneath solid-phase synthesis circumstances utilizing dimer phosphoramidites. These dimers have been constructed following the excessive yielding Michaelis-Arbuzov (M-A) response of nucleoside H-phosphonate derivatives...