Parallel poly(A) homo- and hetero-duplex formation detection with an adapted DNA nanoswitch technique.

Polyriboadenylic (poly(rA)) strands of sufficient length form parallel double helices in acidic and/or ammonium-containing conditions. Poly(rA) duplexes in acidic conditions are held together by A+-A+ base-pairing also involving base interactions with the phosphate backbone.

Traditional UV-melting studies of parallel poly(A) duplexes have typically examined homo-duplex formation of a single nucleic acid species in solution. We have adapted a technique utilizing a DNA nanoswitch that detects interaction of two different strands either with similar or differing lengths or modifications.

SAM FCM (Alexa Fluor 488)

abx098904-60tests 60 tests
EUR 1629.6

FCMR

pro-2579 2µg
EUR 60
Description: Recombinant Human Fc Fragment Of IgM Receptor

FCMR Antibody

E40PV7165 50ul
EUR 395
Description: Available in various conjugation types.

FCMR Antibody

1-CSB-PA007972ESR2HU
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  • 100ul
  • 50ul
Description: A polyclonal antibody against FCMR. Recognizes FCMR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Fcmr Antibody

1-CSB-PA007972LA01MO
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Fcmr. Recognizes Fcmr from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

Fcmr Antibody

CAC10363-100ug 100ug
EUR 314

Fcmr Antibody

CAC10363-50ug 50ug
EUR 199.2

Fc-mDectin-1a

fc-mdec1a-2 2 x 50 µg
EUR 454.65

Human FCMR Protein, Fc Tag

E40KMPH4349 20ug
EUR 495

Human IgM protein (Fc5mu) (HRP)

65C-CH0918 1 mg
EUR 787
Description: Human IgM protein (Fc5mu) (HRP) conjugate

Human IgM protein (Fc5mu) (FITC)

65C-CH0917 1 mg
EUR 598
Description: Human IgM protein (Fc5mu) (FITC) conjugate

FCMTE1 ORF Vector (Human) (pORF)

ORF019527 1.0 ug DNA Ask for price

FCMTE2 ORF Vector (Human) (pORF)

ORF019528 1.0 ug DNA Ask for price

FCMTE3 ORF Vector (Human) (pORF)

ORF019529 1.0 ug DNA Ask for price

FCMTE1 3'UTR GFP Stable Cell Line

TU057841 1.0 ml
EUR 2799.6

FCMTE2 3'UTR GFP Stable Cell Line

TU057842 1.0 ml
EUR 2799.6

FCMTE3 3'UTR GFP Stable Cell Line

TU057843 1.0 ml
EUR 2799.6

Fcmr Polyclonal Antibody

A56202
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  • 100 µg
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Human FCMR Protein Lysate 20ug

IHUFCMRPLLY20UG each
EUR 213
Description: Human FCMR Protein Lysate 20ug

Fcmr Antibody, HRP conjugated

1-CSB-PA007972LB01MO
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Fcmr. Recognizes Fcmr from Mouse. This antibody is HRP conjugated. Tested in the following application: ELISA

Fcmr Antibody, FITC conjugated

1-CSB-PA007972LC01MO
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  • 100ug
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Description: A polyclonal antibody against Fcmr. Recognizes Fcmr from Mouse. This antibody is FITC conjugated. Tested in the following application: ELISA

OACA06922-50UL - FCMR Antibody

OACA06922-50UL 50ul
EUR 189

OAAN01731-50UL - FCMR Antibody

OAAN01731-50UL 50ul
EUR 149

OACA02945-50UG - FCMR Antibody

OACA02945-50UG 50ug
EUR 179

Fcmr Antibody, Biotin conjugated

1-CSB-PA007972LD01MO
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  • 100ug
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Description: A polyclonal antibody against Fcmr. Recognizes Fcmr from Mouse. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACA06922-100UL - FCMR Antibody

OACA06922-100UL 100ul
EUR 230

FCMTE1 Protein Vector (Human) (pPM-C-HA)

PV078107 500 ng Ask for price

FCMTE2 Protein Vector (Human) (pPM-C-HA)

PV078111 500 ng Ask for price

FCMTE3 Protein Vector (Human) (pPM-C-HA)

PV078115 500 ng Ask for price

OAAN01731-100UL - FCMR Antibody

OAAN01731-100UL 100ul
EUR 249

OAAN01731-200UL - FCMR Antibody

OAAN01731-200UL 200ul
EUR 389

OACA02945-100UG - FCMR Antibody

OACA02945-100UG 100ug
EUR 319

FCMR Rabbit Polyclonal Antibody

E10G08305 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FCMR Rabbit Polyclonal Antibody

E10G01349 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Fc Fragment of IgM Receptor (FCMR) Antibody

20-abx320226
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  • 100 ul
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Fc Fragment Of IgM Receptor (FCMR) Antibody

20-abx339450
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  • 100 ul
  • 50 ul

Fc Fragment Of IgM Receptor (FCMR) Antibody

20-abx339609
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  • 100 ul
  • 50 ul

Fc Fragment Of IgM Receptor (FCMR) Antibody

20-abx109287
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  • 100 ug
  • 1 mg
  • 200 ug
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FCMTE1 Protein Vector (Human) (pPB-C-His)

PV078105 500 ng Ask for price

FCMTE1 Protein Vector (Human) (pPB-N-His)

PV078106 500 ng Ask for price

FCMTE1 Protein Vector (Human) (pPM-C-His)

PV078108 500 ng Ask for price

FCMTE2 Protein Vector (Human) (pPB-C-His)

PV078109 500 ng Ask for price

FCMTE2 Protein Vector (Human) (pPB-N-His)

PV078110 500 ng Ask for price

FCMTE2 Protein Vector (Human) (pPM-C-His)

PV078112 500 ng Ask for price

FCMTE3 Protein Vector (Human) (pPB-C-His)

PV078113 500 ng Ask for price

FCMTE3 Protein Vector (Human) (pPB-N-His)

PV078114 500 ng Ask for price

FCMTE3 Protein Vector (Human) (pPM-C-His)

PV078116 500 ng Ask for price

FCMTE1 Recombinant Protein (Human)

RP058578 100 ug Ask for price

FCMTE2 Recombinant Protein (Human)

RP058581 100 ug Ask for price

FCMTE3 Recombinant Protein (Human)

RP058584 100 ug Ask for price

FCMTE1 3'UTR Luciferase Stable Cell Line

TU007841 1.0 ml
EUR 2799.6

FCMTE2 3'UTR Luciferase Stable Cell Line

TU007842 1.0 ml
EUR 2799.6

FCMTE3 3'UTR Luciferase Stable Cell Line

TU007843 1.0 ml
EUR 2799.6

Fc Fragment Of IgM Receptor (FCMR) Antibody (HRP)

20-abx108239
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

OCOA21346-20UG - FCMR Protein Lysate

OCOA21346-20UG 20ug
EUR 169

OCOA01524-20UG - FCMR Protein Lysate

OCOA01524-20UG 20ug
EUR 169

Fc Fragment Of IgM Receptor (FCMR) Antibody (FITC)

20-abx106820
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  • 100 ug
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  • 200 ug
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Fcmr Polyclonal Antibody, HRP Conjugated

A56203
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  • 100 µg
  • 50 ul
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Fc Fragment Of IgM Receptor (FCMR) Antibody (Biotin)

20-abx105401
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  • 100 ug
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FCMR (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each

SR322699 2 nmol Ask for price

Fcmr (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each

SR413999 2 nmol Ask for price

Fcmr Polyclonal Antibody, FITC Conjugated

A56204
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  • 100 µg
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  • 100 ul

Polyclonal FCMR / FAIM3 Antibody (C-Terminus)

APR02365G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FCMR / FAIM3 (C-Terminus). This antibody is tested and proven to work in the following applications:

Fcmr Polyclonal Antibody, Biotin Conjugated

A56205
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  • 100 µg
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ARP76846_P050-25UL - FCMR Antibody - middle region

ARP76846_P050-25UL 25ul
EUR 99

FAIM3 (FCMR) rabbit polyclonal antibody, Purified

AP07299PU-N 50 µg Ask for price

Rat Fcmr / Fas apoptotic inhibitory molecule 3 ELISA Kit

E15361r 96T
EUR 796

FCMTE1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV725231 1.0 ug DNA Ask for price

FCMTE1 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV725235 1.0 ug DNA Ask for price

FCMTE2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV725237 1.0 ug DNA Ask for price

FCMTE2 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV725241 1.0 ug DNA Ask for price

FCMTE3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV725243 1.0 ug DNA Ask for price

FCMTE3 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV725247 1.0 ug DNA Ask for price

Human FCMR / Fas apoptotic inhibitory molecule 3 ELISA Kit

E15361h 96T
EUR 736

Mouse Fcmr / Fas apoptotic inhibitory molecule 3 ELISA Kit

E15361m 96T
EUR 776

FAIM3 (FCMR) (C-term) rabbit polyclonal antibody, Purified

AP05598PU-N 100 µg Ask for price

Rat Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) ELISA Kit

abx523464-96tests 96 tests
EUR 687.5

FCMTE1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV725236 1.0 ug DNA Ask for price

FCMTE2 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV725242 1.0 ug DNA Ask for price

FCMTE3 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV725248 1.0 ug DNA Ask for price

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx004832-100l 100 µl
EUR 400

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx004832-20l 20 µl
EUR 175

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx004832-50l 50 µl
EUR 275

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx109287-100l 100 µl
EUR 162.5

Human Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) CLIA Kit

abx196349-100g 100 µg Ask for price

Human Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) CLIA Kit

abx196349-50g 50 µg
EUR 618.75

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx320226-100l 100 µl
EUR 350

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx320226-50l 50 µl
EUR 237.5

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx339450-100g 100 µg Ask for price

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx339450-20g 20 µg
EUR 250

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx339450-50g 50 µg
EUR 350

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx339609-100g 100 µg Ask for price

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx339609-20g 20 µg
EUR 250

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody

abx339609-50g 50 µg
EUR 350

Fcmr - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL702402 5 µg/vial Ask for price

Human Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) ELISA Kit

abx252429-1096tests 10 × 96 tests Ask for price

Human Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) ELISA Kit

abx252429-596tests 5 × 96 tests Ask for price

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody (HRP)

abx108239-100g 100 µg
EUR 362.5

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody (HRP)

abx108239-20g 20 µg
EUR 162.5

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody (HRP)

abx108239-50g 50 µg
EUR 250

Mouse Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) ELISA Kit

abx523463-96tests 96 tests
EUR 687.5

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody (FITC)

abx106820-100g 100 µg
EUR 362.5

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody (FITC)

abx106820-20g 20 µg
EUR 162.5

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody (FITC)

abx106820-50g 50 µg
EUR 250

Human Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Protein

abx653340-100g 100 µg
EUR 4525

Human Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Protein

abx653340-200g 200 µg Ask for price

Human Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Protein

abx653340-50g 50 µg
EUR 1800

Human Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Protein

abx680537-100g 100 µg
EUR 325

Human Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Protein

abx680537-20g 20 µg
EUR 225

Fcmr - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL504271 5 µg/vial Ask for price

FCMR - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL313098 5 µg/vial Ask for price

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody (Biotin)

abx105401-100g 100 µg
EUR 362.5

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody (Biotin)

abx105401-20g 20 µg
EUR 162.5

Fas Apoptotic Inhibitory Molecule 3 / FAIM3 (FCMR) Antibody (Biotin)

abx105401-50g 50 µg
EUR 250

FCMTE1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV725232 1.0 ug DNA Ask for price

FCMTE2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV725238 1.0 ug DNA Ask for price

FCMTE3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV725244 1.0 ug DNA Ask for price

Recombinant Mouse Fas apoptotic inhibitory molecule 3 (Fcmr), partial

CSB-EP007972MO 1142 mg Ask for price

FCMTE1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV725233 1.0 ug DNA Ask for price

FCMTE1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV725234 1.0 ug DNA Ask for price

FCMTE2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV725239 1.0 ug DNA Ask for price

FCMTE2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV725240 1.0 ug DNA Ask for price

FCMTE3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV725245 1.0 ug DNA Ask for price

FCMTE3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV725246 1.0 ug DNA Ask for price

Recombinant Mouse Fas apoptotic inhibitory molecule 3 (Fcmr) ,partial

RPC21299-100ug 100ug
EUR 705.1

Recombinant Mouse Fas apoptotic inhibitory molecule 3 (Fcmr) ,partial

RPC21299-1mg 1mg
EUR 3237

Recombinant Mouse Fas apoptotic inhibitory molecule 3 (Fcmr) ,partial

RPC21299-20ug 20ug
EUR 353.4

Fcmr - Rat, 4 unique 29mer shRNA constructs in retroviral untagged vectorr

TR702402 5 µg/vial Ask for price

Our method detected parallel duplex formation as a function of length, chemical modifications, and pH, and at a sensitivity that required over 100 fold less concentration of sample than prior UV-melting methods. While parallel polyriboadenylic acid and poly-2′-O-methyl-adenylic acid homo-duplexes formed, we did not detect homo-duplexes of polydeoxyriboadenylic acid strands or poly-locked nucleic acid (LNA)-adenylic strands.

Importantly however, a poly-locked nucleic acid (LNA)-adenylic strand, as well as a poly-2′-O-methyl-adenylic strand formed a hetero-duplex with a polyriboadenylic strand. Overall, our work validates a new tool for studying parallel duplexes and reveals fundamental properties of poly(A) parallel duplex formation. Parallel duplexes may find use in DNA nanotechnology and in molecular biology applications such as a potential poly(rA) tail capture tool as an alternative to traditional oligo(dT) based purification.